Key result
Familial hypercholesterolemia was associated with higher mean platelet volume compared to matched controls.
Why the study?
Is mean platelet volume increased in patients with familial hypercholesterolemia compared to matched controls?
Case-Control (n=324)
Is mean platelet volume increased in patients with familial hypercholesterolemia compared to matched controls?
Patients with familial hypercholesterolemia have increased mean platelet volume, which is independently associated with total cholesterol levels, suggesting a potential mechanism for increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Suggests platelet activation may contribute to CV risk in FH; hypothesis-generating and should not yet change practice.
Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism and increases the risk of premature cardiovascular diseases. In patients with FH, platelet function may be activated; however, the extent of this activation and its etiology are unclear. We aimed to evaluate the mean platelet volume (MPV), a marker of platelet activation, in patients with FH. The study group consisted of 164 patients with FH and 160 control patients. Controls were matched for age, gender, hypertension, and smoking. The MPV was significantly higher in patients with FH than in controls (9.2 ± 0.4 vs 7.9 ± 0.6 fL, respectively; P < .001). Platelet count was significantly lower among patients with FH when compared to control patients (259 ± 51 vs 272 ± 56 × 10(3)/L, respectively; P = .03). In linear regression analysis, MPV was independently associated only with total cholesterol (β = .6, 95% confidence interval: 0.004-0.008, P < .001). We have shown that MPV was increased in patients with FH and that it was independently associated with total cholesterol level.
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İçli et al. (2015) conducted a case-control in Familial hypercholesterolemia (n=324). Familial hypercholesterolemia vs. Matched controls was evaluated on Mean platelet volume (MPV) (p=<.001). Familial hypercholesterolemia was associated with higher mean platelet volume compared to matched controls.
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