Key result
Patients with low HDL-C had significantly higher mean platelet volume compared to controls (8.7 ± 0.6 vs 7.1 ± 0.5 fL; P<.001).
Why the study?
Is mean platelet volume elevated in patients with low high-density lipoprotein cholesterol?
Case-Control (n=115)
Is mean platelet volume elevated in patients with low high-density lipoprotein cholesterol?
Absolute Event Rate: 8.7% vs 7.1%
p-value: p=<.001
Patients with low HDL-C have significantly elevated mean platelet volume, suggesting a potential mechanism for their increased cardiovascular risk.
Should not yet change practice; leaves open whether elevated MPV mediates thrombotic risk in low HDL-C.
A low high-density lipoprotein cholesterol (HDL-C) level is a predictor of increased cardiovascular risk. We assessed the mean platelet volume (MPV) in patients with low HDL-C. We studied 59 patients with low HDL-C (HDL-C ≤35 mg/dL) and 56 control participants (HDL-C levels >35 mg/dL) with similar cardiovascular risk factors. As expected, HDL-C was significantly lower among the patients with low HDL-C than that of the control group (32 ± 3 vs 51 ± 5 mg/dL, respectively; P < .001). Platelet count was significantly lower among the patients with low HDL-C than that of the control group (213 ± 60 vs 285 ± 75 × 10(9)/L, respectively; P < .001). The MPV was significantly higher among the patients with low HDL-C than that of the control group (8.7 ± 0.6 vs 7.1 ± 0.5 fL, respectively; P < .001). We have shown that MPV was significantly elevated in patients with low HDL-C compared with control participants.
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Varol et al. (2013) conducted a case-control in Low High-Density Lipoprotein Cholesterol (n=115). Low HDL-C (≤35 mg/dL) vs. Control participants (HDL-C >35 mg/dL) was evaluated on Mean platelet volume (MPV) (p=<.001). Patients with low HDL-C had significantly higher mean platelet volume compared to controls (8.7 ± 0.6 vs 7.1 ± 0.5 fL; P<.001).
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