Why the study?
Does low HDL cholesterol concentration correlate with disturbances in platelet function in healthy male subjects?
Does low HDL cholesterol concentration correlate with disturbances in platelet function in healthy male subjects?
Low HDL cholesterol does not appear to be associated with significant disturbances in general in vitro platelet function in healthy men.
Low HDL not linked to platelet dysfunction in healthy men; leaves open targeted HDL-platelet factor 3 interactions.
Two groups of healthy male subjects one with low (mean 1.03 mmol/l), and the other with normal (mean 1.80 mmol/l), concentrations of high density lipoprotein (HDL) cholesterol in plasma were investigated. A series of in vitro platelet function tests were performed in order to investigate a possible connection between low HDL concentration, which has been defined as an independent risk factor for the occurrence of CHD, and disturbances in platelet function. No significant differences in platelet function were observed between the two groups. A positive correlation was found between platelet factor 3 activity both in platelet rich and platelet poor plasma and the plasma concentration of HDL.
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Nordøy et al. (1979) studied this question.
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