Why the study?
Deep-water animals accumulate seafood-derived TMAO to protect proteins against hydrostatic pressure stress, leading researchers to hypothesize that TMAO exerts beneficial circulatory effects and protects cardiac LDH against hydrostatic pressure stress from the contracting heart.
Does oral TMAO improve survival and cardiovascular parameters in rat models of heart failure?
Does oral TMAO improve survival and cardiovascular parameters in rat models of heart failure?
In a rat model of heart failure, oral TMAO administration reduced mortality and improved hemodynamics, suggesting potential beneficial diuretic and natriuretic effects.
Hypothesis-generating in HF rat model; leaves open any role for TMAO in human disease.
Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circulatory system and protects cardiac LDH exposed to HPS produced by the contracting heart. Male, Sprague-Dawley and Spontaneously-Hypertensive-Heart-Failure (SHHF) rats were treated orally with either water (control) or TMAO. In vitro, LDH with or without TMAO was exposed to HPS and was evaluated using fluorescence correlation spectroscopy. TMAO-treated rats showed higher diuresis and natriuresis, lower arterial pressure and plasma NT-proBNP. Survival in SHHF-control was 66% vs 100% in SHHF-TMAO. In vitro, exposure of LDH to HPS with or without TMAO did not affect protein structure. In conclusion, TMAO reduced mortality in SHHF, which was associated with diuretic, natriuretic and hypotensive effects. HPS and TMAO did not affect LDH protein structure.
No takes yet. Share an insight, caveat, or question.
Gawryś-Kopczyńska et al. (2020) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: