What question did this study set out to answer?

To localize and characterize angiotensin II receptor binding sites across subcortical structures of the human central nervous system.

October 8, 1991The Journal of Comparative Neurology

Localization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum

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Population

Human central nervous system tissue (basal ganglia, thalamus, midbrain, pons, and cerebellum)

Design

Preclinical

Authors

AAAndrew M. AllenThe University of Melbourne GPGeorge PaxinosUNSW Sydney MMMichael J. McKinleyMental Health Research Institute

Discussion

Member takes

Implication

Does not alter clinical practice; leaves open functional roles of Ang II receptors in human midbrain nuclei.

Key Points

To localize and characterize angiotensin II receptor binding sites across subcortical structures of the human central nervous system.
Conducted in vitro autoradiography on human postmortem brain tissue sections encompassing the thalamus, basal ganglia, midbrain, pons, and cerebellum.
Utilized 125I-[Sar1, Ile8]angiotensin II as the radioligand to identify receptor binding distribution and pharmacological characteristics.
High-density angiotensin II receptor binding localized to the substantia nigra pars compacta, interpeduncular nucleus, raphe magnus, and median raphe nucleus.
Receptor binding in the substantia nigra occurred specifically over pigmented, presumably dopaminergic neurons, an anatomical distribution not detected in other studied species.
Moderate binding densities were identified in the caudate nucleus, putamen, bed nucleus of the stria terminalis, and locus coeruleus, with low densities found in the cerebellum and mediodorsal thalamic nucleus.

Structured PICO

Population

Human central nervous system tissue (basal ganglia, thalamus, midbrain, pons, and cerebellum)

Intervention

In vitro autoradiography employing 125I-[Sar1, Ile8]angiotensin II as the radioligand

Outcome

Localization and density of Angiotensin II receptor binding sitessurrogate

This study maps the discrete distribution of Angiotensin II receptors in the human brain, highlighting unique high-density binding in the substantia nigra over presumably dopaminergic neurons.

Cite This Study

Allen et al. (1991) studied this question.

synapsesocial.com/papers/6a8651b780e29fc8e54ca1dd https://doi.org/10.1002/cne.903120211

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Localization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Localization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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