Population
Foot-and-mouth disease virus (FMDV) model
Comparison
RNA polymerase I transcription system for… vs Wild-type virus
Design
Preclinical
Authors
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PolI-based FMDV reverse genetics may aid functional studies; leaves open vaccine applications pending further validation.
The development of an efficient in vivo RNA polymerase I transcription system allows for the recovery of infectious FMDV from cDNAs, providing a tool for studying FMDV functional genomics and developing genetically engineered vaccines.
Chang et al. (2009) studied this question.
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