What question did this study set out to answer?

To evaluate 12-month changes in health-related quality of life across heart failure subtypes and assess their association with 3-year death or rehospitalization.

August 19, 2020Journal of the American Heart AssociationOpen Access

Change of Health‐Related Quality of Life Over Time and Its Association With Patient Outcomes in Patients With Heart Failure

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Why the study?

Defining health-related quality of life changes over time in patients with HFpEF or reduced ejection fraction and their association with clinical events could support their use in quantifying HF care.

Does a decline in health-related quality of life over 12 months predict death or rehospitalization in patients with heart failure?

Key Points

To evaluate 12-month changes in health-related quality of life across heart failure subtypes and assess their association with 3-year death or rehospitalization.
Prospective cohort analysis of 621 participants categorized into healthy controls (n=98), at risk (n=163), HFpEF (n=191), and HFrEF (n=169) from the Alberta HEART study.
Tracked 12-month changes in health-related quality of life using the Kansas City Cardiomyopathy Questionnaire (KCCQ), EuroQOL 5 dimensions, and Functional Assessment of Cancer Therapy—Anemia.
Assessed the association between 12-month score trajectories and a 3-year composite endpoint of death or rehospitalization.
At 12 months, 30.5% of heart failure patients had ≥5-point improvements and 32.4% had ≥5-point worsening on the KCCQ overall summary score, which did not differ between HFpEF and HFrEF (P=0.23).
Patients with a 12-month decline in KCCQ experienced significantly higher rates of 3-year death or rehospitalization compared with those with stable scores (70.2% versus 52.0%, P=0.012).

Structured PICO

Does a decline in health-related quality of life over 12 months predict death or rehospitalization in patients with heart failure?

Population

621 participants from the Alberta HEART cohort, categorized into healthy controls (n=98), at risk (n=163), HFpEF (n=191), and HFrEF (n=169).

Intervention

Decline in health-related quality of life (KCCQ score) over 12 months

Comparator

Stable KCCQ scores over 12 months

Outcome

Composite of death or rehospitalization within 3 yearscomposite

A decline in health-related quality of life over 12 months is associated with a significantly higher risk of death or rehospitalization in patients with heart failure.

Discussion

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Implication

KCCQ changes over 12 months associate with death/rehospitalization in HFpEF; leaves open whether routine HRQoL monitoring improves care or outcomes.

Cite This Study

Sepehrvand et al. (2020) studied this question.

synapsesocial.com/papers/6a8670d1e3ff5bf5642ed33c https://doi.org/10.1161/jaha.120.017278

Topics

HFrEF treatment Heart failure Heart failure hospitalization HFpEF management

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Implication

KCCQ changes over 12 months associate with death/rehospitalization in HFpEF; leaves open whether routine HRQoL monitoring improves care or outcomes.

Change of Health‐Related Quality of Life Over Time and Its Association With Patient Outcomes in Patients With Heart Failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Change of Health‐Related Quality of Life Over Time and Its Association With Patient Outcomes in Patients With Heart Failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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