Why the study?
Biochemical identification of carotid artery stenosis remains a clinical challenge.
Can serum metabolomics profiles identify and predict the severity of extracranial carotid artery stenosis in male stroke patients compared to normal controls?
Population
349 male subjects including 173 stroke patients with extracranial CAS and 176 normal controls
Comparison
Stroke patients with extracranial CAS ≥ 50% vs normal controls
Design
Case-control study
Authors
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Metabolite profiling in CAS is hypothesis-generating; prospective validation required before any clinical application.
Can serum metabolomics profiles identify and predict the severity of extracranial carotid artery stenosis in male stroke patients compared to normal controls?
Specific serum metabolites, including acylcarnitines, amino acids, and glycerophospholipids, show high specificity but low sensitivity for detecting carotid artery stenosis severity in male stroke patients.
Lin et al. (2022) studied this question.
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