What question did this study set out to answer?

To validate and assess the navigation accuracy of a novel algorithm that integrates preablation CT and MRI imaging with real-time catheter geometry.

August 12, 2009Journal of Cardiovascular Electrophysiology

Dynamic Registration of Preablation Imaging With a Catheter Geometry to Guide Ablation in a Swine Model: Validation of Image Integration and Assessment of Catheter Navigation Accuracy

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Why the study?

Does a novel CT and MRI image integration algorithm provide accurate catheter navigation for ablation in a swine model?

Key Points

To validate and assess the navigation accuracy of a novel algorithm that integrates preablation CT and MRI imaging with real-time catheter geometry.
Sutured epicardial target markers to each cardiac chamber via lateral thoracotomy in 12 swine.
Integrated detailed preacquired CT and MRI anatomical models with catheter chamber geometry using a novel dynamic registration algorithm.
Delivered a single radiofrequency ablation lesion to each endocardial target guided solely by the integrated images, then measured lesion-to-target error at autopsy.
Mean positioning error for CT versus MRI was 2.5 ± 2.4 mm versus 5.1 ± 3.9 mm in the left atrium, and 4.7 ± 3.4 mm versus 3.1 ± 2.7 mm in the left ventricle.
Mean positioning error for CT versus MRI was 6.2 ± 6.5 mm versus 4.3 ± 2.2 mm in the right atrium, and 6.2 ± 4.3 mm versus 6.6 ± 5.3 mm in the right ventricle.
No complications of cardiac perforation or pericardial tamponade occurred during navigation or ablation.

Structured PICO

Does a novel CT and MRI image integration algorithm provide accurate catheter navigation for ablation in a swine model?

Population

12 swine with markers sutured to the epicardial surface of each cardiac chamber

Intervention

Catheter navigation and radiofrequency ablation guided by a novel CT and MRI image integration algorithm

Outcome

Distance from the endocardial RF lesion to the target site (mean position error) assessed at autopsysurrogate

A novel CT and MRI image integration algorithm provides accurate catheter navigation and effective guidance for ablation in a preclinical swine model.

Discussion

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Implication

Supports preclinical validation of CT/MRI integration; leaves open translation to human catheter ablation accuracy and safety.

Cite This Study

West et al. (2009) studied this question.

synapsesocial.com/papers/6a86921aa063193d080cfa22 https://doi.org/10.1111/j.1540-8167.2009.01572.x

Topics

AF ablation outcomes

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Dynamic Registration of Preablation Imaging With a Catheter Geometry to Guide Ablation in a Swine Model: Validation of Image Integration and Assessment of Catheter Navigation Accuracy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Dynamic Registration of Preablation Imaging With a Catheter Geometry to Guide Ablation in a Swine Model: Validation of Image Integration and Assessment of Catheter Navigation Accuracy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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