Why the study?
Does hypoxic preconditioning of CLK cells improve infarct size and heart function in a murine myocardial infarction model?
Population
Murine myocardial infarction model
Comparison
Intravenously administered… vs CLK cells cultured under normoxic conditions
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypoxia-preconditioned CLK cells improve murine post-MI repair; leaves open clinical translation and requires prospective human trials.
Does hypoxic preconditioning of CLK cells improve infarct size and heart function in a murine myocardial infarction model?
Hypoxic preconditioning enhances the recruitment and efficacy of cardiac progenitor cells in a murine myocardial infarction model via the SDF-1/CXCR4 axis.
Tang et al. (2009) studied this question.
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