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January 31, 2004AJP Renal Physiology

Aldosterone enhances renin gene expression in juxtaglomerular cells

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Population

Primary cultures of mouse juxtaglomerular cells and mouse juxtaglomerular cell line As4.1

Design

Preclinical

Authors

JKJürgen KlarHVHelga VitzthumAKArmin Kurtz

Discussion

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Overview

Preclinical aldosterone-renin effects should not change RAAS inhibitor practice; leaves open translational relevance to human hypertension models.

Structured PICO

P
Population
Primary cultures of mouse juxtaglomerular cells and mouse juxtaglomerular cell line As4.1
I
Intervention
Aldosterone (100 nM)
O
Outcome
Renin mRNA levels and prorenin secretionsurrogate

Aldosterone exerts a direct positive effect on renin gene expression at the cellular level, likely by stabilizing renin mRNA.

Cite This Study

Klar et al. (2004) studied this question.

synapsesocial.com/papers/6a86ad7d241d06231dbee878https://doi.org/10.1152/ajprenal.00411.2002
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular control of renin secretion1999 · 63 citations
  2. 2Critical Roles of a Cyclic AMP Responsive Element and an E-box in Regulation of Mouse Renin Gene Expression2001 · 134 citations
  3. 3Human Renin mRNA Stability Is Increased in Response to cAMP in Calu-6 Cells1999 · 41 citations
  4. 4Biosynthesis of Renin in Mouse Kidney Tumor As4.1 Cells1997 · 30 citations