Population
Intact spontaneously breathing rats (ISBR) and isolated perfused rat lungs in vitro
Comparison
Novel cardiac catheterization technique for in… vs Isolated perfused rat lungs in vitro
Design
Preclinical
Authors
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Urges caution extrapolating in vitro pulmonary data; extends EDRF role in vivo models but leaves open clinical relevance.
A novel in vivo catheterization technique in rats demonstrates significant differences in pulmonary vascular responses compared to in vitro models, highlighting the role of EDRF in pulmonary hypertension.
Hyman et al. (1998) studied this question.
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