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August 20, 2026Clinical Nephrology

Association between perioperative diuretic use and postoperative outcomes following Mohs micrographic surgery

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Authors

NSNehaa SohailSZSabrina ZhengZZZuhair Zaidi

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Overview

Matched cohort study finds increased postoperative complications in Mohs surgery patients taking diuretics, highlighting the need for enhanced perioperative monitoring.

Key Points

  • To investigate the association between perioperative diuretic use and postoperative outcomes in patients undergoing Mohs micrographic surgery (MMS).
  • Retrospective 1:1 matched cohort study using the TriNetX database analyzing N = 37,781 matched patients undergoing MMS.
  • Assessed postoperative outcome variables across 30- and 90-day follow-up intervals based on perioperative diuretic exposure.
  • Diuretic use was associated with increased odds of surgical site infection at 30 days (OR 1.29, 95% CI 1.03–1.62, p = 0.03) and 90 days (OR 1.36, 95% CI 1.12–1.65, p < 0.001).
  • Odds of rash or cellulitis were significantly elevated at 30 days (OR 1.95, 95% CI 1.68–2.26, p < 0.001) and 90 days (OR 1.92, 95% CI 1.74–2.13, p < 0.001).
  • Diuretic exposure was linked to increased risks of postoperative pain, opioid use, emergency department visits, sepsis, and short-term mortality, with loop and osmotic diuretics identified as primary drivers.

Cite This Study

Sohail et al. (2026) studied this question.

synapsesocial.com/papers/6a86b56c8a91293e6a1ccbfbhttps://doi.org/10.5414/cn112145
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