Why the study?
Is the dynamic Starling mechanism impaired in patients with HFpEF compared to healthy controls when LVEDP is normalized?
Population
10 patients with heart failure with preserved ejection fraction and 12 age-matched healthy controls
Comparison
Preload manipulation using lower-body negative… vs Age-matched healthy controls undergoing the same…
Design
Case-control
Authors
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Impaired DSM at matched LVEDP supports intrinsic diastolic dysfunction in HFpEF; leaves open ventricular-arterial coupling mechanisms.
Is the dynamic Starling mechanism impaired in patients with HFpEF compared to healthy controls when LVEDP is normalized?
The dynamic Starling mechanism is severely impaired in HFpEF patients even when LVEDP is normalized, suggesting intrinsic left-ventricular diastolic dysfunction and ventricular-arterial coupling incompetence.
Hieda et al. (2017) studied this question.
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