Why the study?
How do rate nephelometry and homogenous enzyme immunoassay compare to high-performance liquid chromatography for measuring total and unbound quinidine concentrations?
Population
Samples from 46 patients
Comparison
Rate nephelometry and homogenous enzyme… vs High-performance liquid chromatography (HPLC)
Design
Other
Authors
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May warrant HPLC preference for quinidine monitoring to avoid overestimation errors; leaves open need for modern assay validation studies.
How do rate nephelometry and homogenous enzyme immunoassay compare to high-performance liquid chromatography for measuring total and unbound quinidine concentrations?
HPLC is the method of choice for determining both total and unbound serum quinidine concentrations, as EMIT and ICS can produce unacceptably high errors.
Wooding‐Scott et al. (1989) studied this question.
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