Key result
A specific high-performance liquid chromatography assay for serum quinidine correlated well with the double-extraction method (r = 0.975).
Population
Patients' sera
Comparison
High-performance liquid chromatography assay for… vs Double-extraction method of Cramer and Isaksson
Design
Other
Authors
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May facilitate quinidine level monitoring; leaves open prospective outcome validation before routine adoption.
Effect estimate: r = 0.975
The described HPLC assay provides a rapid and specific method for monitoring serum quinidine concentrations, correlating well with older double-extraction methods.
Crouthamel et al. (1977) studied Patients requiring serum quinidine monitoring. High-performance liquid chromatography assay for serum quinidine vs. Double-extraction method of Cramer and Isaksson was evaluated on Correlation between assay methods for patients' sera (r = 0.975). A specific high-performance liquid chromatography assay for serum quinidine correlated well with the double-extraction method (r = 0.975).
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