Why the study?
Does blood collection technique and heparin exposure affect the measurement of unbound quinidine fraction?
Population
10 normal volunteers, 10 patients with congestive heart failure, 11 patients with chronic renal failure, and…
Comparison
Blood collection using Vacutainers and exposure… vs Blood collection using all-glass equipment…
Design
Other
Authors
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Artifactual quinidine binding changes require all-glass collection; challenges validity of prior unbound fraction data from standard tubes.
Does blood collection technique and heparin exposure affect the measurement of unbound quinidine fraction?
Quinidine binding measurements are significantly altered by blood collection in Vacutainers and by heparin exposure, necessitating the use of all-glass equipment.
Kessler et al. (1979) studied this question.
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