Key result
The degree of quinidine protein binding in plasma of patients with types IV and IIa hyperlipoproteinemias did not differ from that in normal subjects.
Why the study?
Does the degree of quinidine plasma protein binding differ between normal subjects and patients with hyperlipoproteinemias?
Observational
Does the degree of quinidine plasma protein binding differ between normal subjects and patients with hyperlipoproteinemias?
Quinidine plasma protein binding is relatively insensitive to changes in individual serum lipoproteins and does not differ significantly in patients with hyperlipoproteinemias compared to normal subjects.
Answers are grounded in this paper and cite their sources.
Quinidine dosing needs no adjustment for hyperlipoproteinemia; leaves open lipoprotein effects on other drug binding.
Quinidine in the plasma binds to various lipoproteins as well as to albumin. With the use of computer simulations the effect of varying the serum level of each of the lipoproteins as well as albumin was examined. The results suggested that the overall binding of quinidine is relatively insensitive to changes in any one serum protein provided the others are present in normal concentrations. Evaluation of the degree of protein binding of quinidine in plasma from normal subjects and patients with types IV and IIa hyperlipoproteinemias supported the computer predictions. The degree of protein binding in plasma from normal subjects and patients with types IV and IIA hyperlipoproteinemias were 71.2% +/- 11.4%, 75.9% +/- 8.7%, and 69.9% +/- 15.0%, respectively. The quinidine binding in plasma of patients with hyperlipoproteinemias did not differ statistically from that in the normal subjects.
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Kates et al. (1978) conducted an observational in Hyperlipoproteinemia (types IV and IIa). Hyperlipoproteinemia (types IV and IIa) vs. Normal subjects was evaluated on Degree of protein binding of quinidine in plasma. The degree of quinidine protein binding in plasma of patients with types IV and IIa hyperlipoproteinemias did not differ from that in normal subjects.
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