What question did this study set out to answer?

To report the therapeutic effects of total ablation of the normal thyroid gland in patients suffering from congestive heart failure or angina pectoris.

August 1, 1933Archives of Internal Medicine

Therapeutic Effect of Total Ablation of Normal Thyroid on Congestive Heart Failure and Angina Pectoris

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Why the study?

Does total ablation of the normal thyroid gland improve outcomes in patients with congestive heart failure or angina pectoris?

Population

10 patients with congestive heart failure or angina pectoris, plus 1 previously reported patient (case 11)

Design

Case_series

Authors

HBHerrman L. BlumgartTufts University

Discussion

Member takes

Implication

Does not support thyroid ablation for heart failure or angina; leaves open any modern relevance of this historical approach.

Key Points

To report the therapeutic effects of total ablation of the normal thyroid gland in patients suffering from congestive heart failure or angina pectoris.
Clinical case series evaluating the effects of total thyroidectomy in 10 patients with congestive heart failure or angina pectoris.
Treatment rationale based on prior physiologic assessments of pulmonary blood flow velocity in over 600 subjects across varying metabolic states.
Physiological measurements confirmed that blood flow velocity is directly governed by metabolic demands, accelerating in thyrotoxicosis and decreasing at lower metabolic rates.
Total thyroid ablation was implemented to lower the basal metabolic rate, thereby reducing circulatory velocity and alleviating mechanical cardiac strain.

Structured PICO

Does total ablation of the normal thyroid gland improve outcomes in patients with congestive heart failure or angina pectoris?

Population

10 patients with congestive heart failure or angina pectoris, plus 1 previously reported patient (case 11)

Intervention

Total ablation of the normal thyroid gland

This historical case series describes the rationale and early clinical course of total thyroid ablation as a treatment for congestive heart failure and angina pectoris.

Cite This Study

Herrman L. Blumgart (1933) studied this question.

synapsesocial.com/papers/6a86c8f5a810ea404bcf858b https://doi.org/10.1001/archinte.1933.00160020003001

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Therapeutic Effect of Total Ablation of Normal Thyroid on Congestive Heart Failure and Angina Pectoris

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Therapeutic Effect of Total Ablation of Normal Thyroid on Congestive Heart Failure and Angina Pectoris

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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