Why the study?
Does total ablation of the normal thyroid gland improve symptoms in patients with chronic heart disease (angina pectoris and congestive failure)?
Does total ablation of the normal thyroid gland improve symptoms in patients with chronic heart disease (angina pectoris and congestive failure)?
This historical case series summarizes early experiences with total thyroid ablation as a treatment for severe angina pectoris and congestive heart failure.
Historical thyroid ablation experiences in refractory angina and HF warrant modern caution; leaves open need for prospective trials.
Our purpose in this communication is to summarize our experience during the last eighteen months in ti eating seventy-five patients with chronic heart disease by removing the entire normal thyroid gland.1Our efforts have been directed in five main directions: (1) clinical appraisal of the therapeutic value of the procedure;2(2) establishment of criteria for the proper selection of patients; (3) reduction in the risk of operation through study of the surgical technic and the best possible preoperative and postoperative care;3(4) study of the mechanisms whereby the development of hypothyroidism results in relief of angina pectoris and congestive failure;4(5) investigation and control of the secondary consequences of the hypothyroid state.5Although final conclusions concerning these problems await the results obtained over a period of years, it may be helpful to state the results based on our present experience. The group of seventy-five patients
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Blumgart et al. (1935) studied this question.
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