The Treatment of Angina Pectoris With Propylthiouracil

Article1 June 1948THE TREATMENT OF ANGINA PECTORIS WITH PROPYLTHIOURACILGEORGE HOLLANDER, M.D., HARRY MANDELBAUM, M.D., F.A.C.P.GEORGE HOLLANDER, M.D., HARRY MANDELBAUM, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-6-1150 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEffective and striking results in the treatment of angina pectoris have been obtained with total thyroidectomy.1, 2Its shortcomings—the risk of surgery, subsequent complications and irreparable loss of thyroid function—have limited its use to patients with a fair life expectancy who are adequate surgical risks. At the present time, drugs which selectively act to block the formation of active thyroid hormone to give rise to a reversible, chemical thyroidectomy, include radioactive iodine and the thiouracil group. In many, these are a medical substitute for surgery, without its discomfort and occasional mortality. The newer, more powerful and less toxic derivatives of...Bibliography1. MIXTERBLUMGARTBERLIN CGHLDD: Total ablation of the thyroid for angina pectoris and congestive heart failure, Ann. Surg., 1934, c, 570. CrossrefGoogle Scholar2. CUTLERHOERR ECSO: Total thyroidectomy for heart disease. A five-year follow-up study, Ann. Surg., 1941, cxiii, 245. Google Scholar3. RAAB W: Thiouracil treatment of angina pectoris, Jr. Am. Med. Assoc., 1945, cxxviii, 249. CrossrefGoogle Scholar4. BEN-ASHER S: Treatment of anginal syndrome with thiouracil, Jr. Med. Soc. New Jersey, 1945, xlii, 401. Google Scholar5. REVENO W: Thiouracil in angina pectoris, Am. Jr. Med., 1946, i, 607. CrossrefGoogle Scholar6. DIPALMAMAGOVERN JRJJ: Disadvantages of thiouracil treatment of angina pectoris, Am. Heart Jr., 1946, xxxii, 494. CrossrefGoogle Scholar7. Unpublished data. Google Scholar8. ROSENKRANTZMARSHALL JAC: Basal metabolic rate in hypertensive vascular disease, Arch. Int. Med., 1947, lxxx, 81. CrossrefGoogle Scholar9. PARKERDRYWILLIUSGAGE RLTJFARP: Life expectancy in angina pectoris, Jr. Am. Med. Assoc., 1946, cxxxi, 95. CrossrefGoogle Scholar10. BLUMGARTLEVINEBERLINE HLSADD: Congestive heart failure and angina pectoris: the therapeutic effect of thyroidectomy on patients without clinical of pathologic evidence of thyroid toxicity, Arch. Int. Med., 1933, li, 866. CrossrefGoogle Scholar11. LEVINEEPPINGER SAEC: Further experiences with total thyroidectomy in the treatment of intractable heart disease, Am. Heart Jr., 1935, x, 735. Google Scholar12. WEISSELLIS SLB: The quantitative aspects and dynamics of the circulatory mechanism in arterial hypertension, Am. Heart Jr., 1930, v, 448. CrossrefGoogle Scholar13. ESTESKEITH JENM: Hypothyroidism and mild myxedema from thiocyanate intoxication, Am. Jr. Med., 1946, i, 45. CrossrefGoogle Scholar14. ASTWOOD EB: Quoted by Reveno.5 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication September 6, 1947.From the Hypertensive Service, Department of Medicine, The Jewish Hospital, Brooklyn, N. Y.Propylthiouracil was supplied through the courtesy of Dr. S. M. Hardy, Lederle Laboratories, Inc., Pearl River, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe heart in hypothyroidismDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktTreatment of Angina PectorisThe Lewis A. Conner Memorial LectureTREATMENT OF ANGINA PECTORIS WITH PROPYLTHIOURACIL*LEO WAITZKIN, M.D.VALUE OF ELECTROMYOGRAPHY IN CLINICAL NEUROLOGYCARDIAC FAILUREHypothyroidism Produced by Radioactive Iodine (I 131 ) in the Treatment of Euthyroid Patients with Angina Pectoris and Congestive Heart FailureNeurohormanal bedingte Herzkrankheiten (Pathogenese und Therapie)Propyl-Thiouracil for Angina Pectoris1 1 June 1948Volume 28, Issue 6Page: 1150-1156KeywordsAnginaDrugsHospital medicineLife expectancyMortalityRiversSurgeryThyroid hormonesThyroidectomy ePublished: 1 December 2008 Issue Published: 1 June 1948 PDF downloadLoading ...