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Hypothesis-generating for antithyroid agents in angina; leaves open any modern therapeutic role.
Article1 March 1950PROPYLTHIOURACIL IN THE TREATMENT OF ANGINA PECTORIS: A COMPARISON WITH THIOURACIL THERAPYSOLOMON BEN-ASHER, M.D.SOLOMON BEN-ASHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-3-528 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe effectiveness of thiouracil in the treatment of the anginal syndrome was first described by Raab1and Ben-Asher2in 1945. Clinical improvement was obtained in seven of 10 patients treated by Raab and in eight patients treated by the author. The following year DiPalma and MaGovern3emphasized the disadvantages of thiouracil in the treatment of angina pectoris. They found, however, that the precordial pain was beneficially affected at least for a period of time in four of their eight patients. In the same year Reveno4described eight patients with angina pectoris treated with the drug. 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Bevelander G: Effect of thiourea on development of sea urchin Arbacia punctulata , Proc. Soc. Exper. Biol. and Med. 61: 268, 1946. CrossrefMedlineGoogle Scholar32. Lundsgaard E: Untersuchungen über Muskelkontraktionen ohne Milchsäuerbildung, Biochem. Ztschr. 217: 162, 1930. Google Scholar33. Lundsgaard E: Weitere Untersuchungen über Muskelkontraktionen ohne Milchsäuerbildung, Biochem. Ztschr. 51: 227, 1930. Google Scholar34. Lundsgaard E: Phosphogen und Pyrophosphatumsatz in jodessigsauer vergifteten Muskeln, Biochem. Ztschr. 269: 308, 1934. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jersey City, New Jersey*Received for publication April 15, 1948.From the medical departments and the cardiac clinics of the Medical Center and of the Greenville Hospital, Jersey City, New Jersey.Propylthiouracil was supplied through the courtesy of Dr. Stanton M. Hardy of the Lederle Laboratories, Inc., Pearl River, New York.†Dr. Ben-Asher died on April 27, 1949. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und Herzinfarkt 1 March 1950Volume 32, Issue 3Page: 528-541KeywordsAnginaDrugsHospitalsRivers ePublished: 1 December 2008 Issue Published: 1 March 1950 PDF downloadLoading ...
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