Why the study?
Does total ablation of the thyroid improve outcomes in patients with congestive heart failure and angina pectoris without thyrotoxicosis?
Does total ablation of the thyroid improve outcomes in patients with congestive heart failure and angina pectoris without thyrotoxicosis?
This historical paper discusses the rationale for total thyroid ablation to reduce cardiac demands in patients with refractory angina pectoris and congestive heart failure.
Hypothesis-generating rationale for thyroid ablation in refractory HF and angina; leaves open modern efficacy without trials.
Article1 June 1934TREATMENT OF ANGINA PECTORIS AND CONGESTIVE HEART FAILURE BY TOTAL ABLATION OF THE THYROID IN PATIENTS WITHOUT THYROTOXICOSISX. WITH PARTICULAR REFERENCE TO THE PRE- AND POSTOPERATIVE MEDICAL MANAGEMENT*H. L. BLUMGART, D. D. BERLIN, DAVID DAVIS, J. E. F. RISEMAN, A. A. WEINSTEINH. L. BLUMGARTSearch for more papers by this author, D. D. BERLINSearch for more papers by this author, DAVID DAVISSearch for more papers by this author, J. E. F. RISEMANSearch for more papers by this author, A. A. WEINSTEINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-12-1469 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the treatment of patients with congestive failure and angina pectoris, one not infrequently finds that despite all available medical measures the patients, while improved, nevertheless continue to remain chronically incapacitated. It is well recognized that exercise, emotion and other factors which increase cardiac work tend to increase congestive heart failure and angina pectoris. The enforcement of diminished activity or complete bed rest benefits patients by reducing the demands on the heart. The use of sedatives and the action of digitalis in reducing the ventricular rate in auricular fibrillation have a similar effect.3,10,27The same considerations underlie the treatment of...Bibliography1. 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MEANS JH: Address on certain aspects of pathogenesis of angina pectoris, Canad. Med. Assoc. Jr., 1931, xxiv, 193-200. Google Scholar23. MEANSRICHARDSON JHEP: The diagnosis and treatment of diseases of the thyroid; in CHRISTIAN, H. A.: Oxford monographs on diagnosis and treatment, vol. 4, 1929, Oxford University Press, New York. Google Scholar24. MEANSWHITEKRANTZ JHPDCI: Heart in myxedema, with special reference to dilatation and angina pectoris, Boston Med. and Surg. Jr., 1926, cxcv, 455-460. CrossrefGoogle Scholar25. RISEMANSTERN JEB: A standardized exercise tolerance test for patients with angina pectoris on exertion. (To be published.) Google Scholar26. WEINSTEINDAVISBERLINBLUMGART AADDDHL: Observations on the mechanism of the early relief of pain in patients with angina pectoris and congestive failure after total ablation of the normal thyroid gland, Am. Jr. Med. Sci. (In press.) Google Scholar27. WEISSBLUMGART SHL: Effect of digitalis bodies on velocity of blood flow through lungs and on other aspects of circulation; study of normal subjects and patients with cardiovascular disease, Jr. Clin. Invest., 1929, vii, 11-26. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read before the American College of Physicians, Chicago, April 17, 1934.From the Medical Service and Research Laboratories of the Beth Israel Hospital, and the Department of Medicine, Harvard Medical School, Boston.This investigation was aided by a grant from the William W. Wellington Memorial Research Fund of the Harvard Medical School, Boston. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFunktionelle StrahlentherapieReferencesExperimentelle Befunde zur Frage gesteigerter Thyroxinempfindlichkeit des mechanisch vermehrt belasteten Herzmuskels 1 June 1934Volume 7, Issue 12Page: 1469-1477KeywordsAnginaHeartHeart failureHospital medicineMedical servicesPatientsResearch fundingResearch laboratoriesSedativesThyroid Issue Published: 1 June 1934 PDF DownloadLoading ...
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Herrman L. Blumgart (1934) studied this question.
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