Population
Human aortic smooth muscle cells (HASMCs) and rat smooth muscle cells
Comparison
Exposure to low shear stress or high shear… vs Stationary control conditions
Design
Preclinical
Follow-up
2 to 24 hours
Authors
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High shear may alter VSMC thrombotic balance; hypothesis-generating for arterial pathology and requires in vivo confirmation.
Shear stress differentially regulates PAR-1 and tPA gene expression in vascular smooth muscle cells, with high shear stress decreasing PAR-1 and increasing tPA expression, which may influence arterial vascular pathologies.
Papadaki et al. (1998) studied this question.
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