Key result
High fluid shear stress increased t-PA relative to GAPDH gene expression by 54 +/- 14% compared to low shear stress in intact human umbilical veins (p = 0.002).
Why the study?
Does high fluid shear stress increase the expression of tissue-type plasminogen activator in intact human conduit vessels compared to low shear stress?
Population
Intact human conduit vessels (human umbilical veins)
Comparison
High shear stress at 20 mmHg intraluminal… vs Low shear stress at identical intraluminal…
Design
Preclinical
Follow-up
up to 6 hours
Authors
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High shear upregulates t-PA expression in human conduit vessels; leaves open effects on in vivo fibrinolysis or thrombosis risk.
Does high fluid shear stress increase the expression of tissue-type plasminogen activator in intact human conduit vessels compared to low shear stress?
Effect estimate: increased by 54 +/- 14%
p-value: p=0.002
High fluid shear stress independently upregulates the intracellular storage pool and gene expression of t-PA in the vascular wall of human conduit vessels.
Sjögren et al. (2000) studied this question. High shear stress vs. Low shear stress (< 4 dyn/cm2) was evaluated on t-PA relative to GAPDH gene expression (increased by 54 +/- 14%, p=0.002). High fluid shear stress increased t-PA relative to GAPDH gene expression by 54 +/- 14% compared to low shear stress in intact human umbilical veins (p = 0.002).
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