Key result
GF109203X significantly inhibited acetylcholine-induced bronchial smooth muscle contraction in rats, suggesting the involvement of the PKC epsilon isoform.
Population
Rat bronchial smooth muscle
Design
Preclinical
Authors
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Does not support clinical translation; leaves open PKC epsilon targeting in airway smooth muscle models.
p-value: p=<0.001
PKC epsilon appears to be the specific isoform involved in acetylcholine-induced bronchial smooth muscle contraction in rats.
Sakai et al. (2008) studied Bronchial smooth muscle contraction. PKC inhibitors (GF109203X, Gö6976, rottlerin) vs. Vehicle (DMSO) was evaluated on Acetylcholine-induced bronchial smooth muscle contraction (p=<0.001). GF109203X significantly inhibited acetylcholine-induced bronchial smooth muscle contraction in rats, suggesting the involvement of the PKC epsilon isoform.
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