Key result
Passive sensitization of human isolated bronchial rings with asthmatic serum decreased the maximal response to PDB compared to normal serum (28.9% vs 46.7% of maximal ACh response; P<0.05).
Absolute Event Rate: 28.9% vs 46.7%
p-value: p=< 0.05
PKC activation induces sustained contractions in human airway smooth muscle dependent on extracellular calcium, and passive sensitization alters this PKC-mediated response.
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Suggests PKC pathway alterations in asthmatic airways; leaves open clinical relevance pending in vivo studies.
Rossetti et al. (1995) studied Human isolated bronchial smooth muscle (n=5). Passive sensitization with atopic asthmatic serum vs. Incubation in serum from normal subjects was evaluated on Maximal response to PDB (% of maximal response to ACh) (p=< 0.05). Passive sensitization of human isolated bronchial rings with asthmatic serum decreased the maximal response to PDB compared to normal serum (28.9% vs 46.7% of maximal ACh response; P<0.05).
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