Key result
The combination of AT1 antagonist losartan and AT2 antagonist PD123319 inhibited ovulation, while PD123319 increased basal ovarian blood flow, indicating cooperative mechanisms in ovulation.
Both AT1 and AT2 receptors cooperatively facilitate ovulation and differentially regulate ovarian blood flow in rats.
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Rat data are hypothesis-generating; leaves open any role for AT1/AT2 modulation in human ovulation.
K Mitsube (2003) studied Preovulatory rat ovaries. Losartan and PD123319 vs. Basal/control was evaluated on Ovulation and ovarian blood flow. The combination of AT1 antagonist losartan and AT2 antagonist PD123319 inhibited ovulation, while PD123319 increased basal ovarian blood flow, indicating cooperative mechanisms in ovulation.
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