Key result
The combination of AT1 and AT2 antagonists inhibited ovulation, and AT2 primarily negatively regulates basal ovarian blood flow in rats.
Both AT1 and AT2 receptors cooperatively facilitate ovulation, but they regulate ovarian blood flow in different manners in rats.
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Rat data on AT1/AT2 in ovulation require human validation; leaves open therapeutic translation.
Mitsube et al. (2003) studied Preovulatory rat ovaries. Losartan and PD123319 vs. Basal conditions / Angiotensin II alone was evaluated on Ovulation and ovarian blood flow. The combination of AT1 and AT2 antagonists inhibited ovulation, and AT2 primarily negatively regulates basal ovarian blood flow in rats.
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