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November 1, 1974The Journal of Clinical Endocrinology & Metabolism

The Validity of Comparing the Measurements of Angiotensin I Generated in Human Plasma by Radioimmunoassay and Bioassay

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Population

Plasma samples from hypertensive and normal subjects

Comparison

Measurement of Angiotensin I by radioimmunoassay vs Measurement of Angiotensin I by bioassay (BA)

Design

Other

Authors

PEPeter EggenaUniversity of California, Los AngelesJBJack BarrettSouth Western Ambulance Service NHS Foundation TrustMSMohinder P. SambhiUniversity of California, Los Angeles

Discussion

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Implication

Subject-specific BA/RIA variability precludes a universal conversion factor for Angiotensin I; challenges assay interchangeability and leaves open individualized calibration.

Structured PICO

P
Population
Plasma samples from hypertensive and normal subjects
I
Intervention
Measurement of Angiotensin I by radioimmunoassay (RIA)
C
Comparator
Measurement of Angiotensin I by bioassay (BA)
O
Outcome
Correlation and ratio between bioassay and radioimmunoassay measurements of Angiotensin Isurrogate

A common conversion factor cannot be used to compare radioimmunoassay and bioassay measurements of Angiotensin I in individual subjects due to significant subject-specific variability.

Cite This Study

Eggena et al. (1974) studied this question.

synapsesocial.com/papers/6a86de8c24dcec08efbef507https://doi.org/10.1210/jcem-39-5-865

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radioimmunoassay of Angiotensin I: Comparison of Two Renin Activity Methods and Use for Other Measurements of the Renin System1972 · 55 citations
  2. 2Application of a Radioimmunoassay for Angiotensin I to the Measurement of Plasma Renin in Rabbits, and Comparison with a Biological Assay of Plasma Renin Activity1975 · 6 citations
  3. 3Measurement of Plasma Renin Activity by Angiotensin I Radioimmunoassay: A Modification of Haber's Method1972 · 68 citations
  4. 4Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects11969 · 2,239 citations
  5. 5Comparison of a Biological and an Immunological Assay for the Measurement of Plasma Renin Activity1973 · 17 citations