Key result
Oxidative stress, driven by NADPH oxidase overactivity and reduced SOD activity, is present in early stages of chronic kidney disease and may be a key mechanism of early atherosclerosis.
Population
Patients with early (stages 1-2) and advanced chronic kidney disease (CKD)
Design
Review
Authors
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Oxidative stress markers should not guide therapy in early CKD yet; leaves open NADPH oxidase inhibition as a target pending trials.
Oxidative stress is present in early stages of chronic kidney disease and may be a key mechanism driving early atherosclerosis and cardiovascular risk in these patients.
Zalba et al. (2006) conducted a review in Chronic kidney disease and atherosclerosis. Oxidative stress was evaluated. Oxidative stress, driven by NADPH oxidase overactivity and reduced SOD activity, is present in early stages of chronic kidney disease and may be a key mechanism of early atherosclerosis.
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