Key result
Tempol treatment in a mouse model of systemic hypertension resulted in modest reductions in wall thickening and circumferential material stiffness, significantly reducing aortic pulse wave velocity.
Why the study?
Tempol reduces adverse aortic remodeling in hypertensive murine models, but its effects lacked detailed assessment of biaxial biomechanics.
Tempol modestly attenuates hypertensive aortic remodeling in mice; leaves open clinical translation of antioxidant effects.
Hypertension-induced arterial remodeling is thought to be a response to increases in both mechanical stress and oxidative stress. The superoxide dismutase mimetic Tempol has been shown to reduce adverse aortic remodeling in multiple murine models of hypertension but in the absence of a detailed assessment of the biaxial biomechanics. We show that concurrent treatment with Tempol in a common mouse model of systemic hypertension results in modest reductions in both wall thickening and circumferential material stiffness that yet work together to achieve a significant reduction in calculated aortic pulse wave velocity. Reducing elevated values of pulse wave velocity engenders multiple benefits to cardiovascular function.
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Niestrawska et al. (2023) studied Hypertension. Tempol was evaluated on Aortic pulse wave velocity, wall thickening, and circumferential material stiffness. Tempol treatment in a mouse model of systemic hypertension resulted in modest reductions in wall thickening and circumferential material stiffness, significantly reducing aortic pulse wave velocity.
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