Key result
The minor G allele of rs2243828 in MPO was significantly associated with a lower risk of atrial fibrillation in two independent Chinese populations (OR 0.77, P=6.25x10^-3; OR 0.75, P=9.88x10^-5).
Why the study?
Myeloperoxidase levels are elevated in patients with AF, but genetic evidence linking MPO to AF risk in human populations was lacking.
Does the minor G allele of rs2243828 in the MPO gene associate with the risk of atrial fibrillation in the Chinese Han population?
Case-Control (n=4,011)
Yes
Does the minor G allele of rs2243828 in the MPO gene associate with the risk of atrial fibrillation in the Chinese Han population?
Odds Ratio: 0.77
p-value: p=6.25 × 10^-3
The minor G allele of rs2243828 in the MPO gene is associated with lower myeloperoxidase levels and a reduced risk of atrial fibrillation in the Chinese Han population, providing genetic evidence linking inflammation to AF incidence.
Previous studies shown that myeloperoxidase (MPO) level is higher in patients with atrial fibrillation (AF); however, no genetic evidence between MPO and AF risk in human population was observed. Therefore, the present study was aimed to investigate the association between rs2243828, a variant in promoter region of MPO and the risk of AF in Chinese GeneID population. The results demonstrated that the minor G allele of rs2243828 showed a significant association with AF in two independent population (GeneID‐north population with 694 AF cases and 710 controls, adjusted P ‐adj = 6.25 × 10 −3 with an odds ratio was 0.77, GeneID‐central population with 1106 cases and 1501 controls, P ‐adj = 9.88 × 10 −5 with an odds ratio was 0.75). The results also showed G allele was significantly associated with lower plasma concentration of myeloperoxidase in general population. We also observed a significant difference of odds ratio between subgroups of hypertension and non‐hypertension. Therefore, our findings identified variant in MPO associated with risk of AF and it may give strong evidence to link the inflammation with the incidence of AF.
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Wang et al. (2020) conducted a case-control in Atrial fibrillation (n=4,011). Minor G allele of rs2243828 in MPO vs. Major allele was evaluated on Atrial fibrillation risk (OR 0.77, p=6.25 × 10^-3). The minor G allele of rs2243828 in MPO was significantly associated with a lower risk of atrial fibrillation in two independent Chinese populations (OR 0.77, P=6.25x10^-3; OR 0.75, P=9.88x10^-5).
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