Key result
Intense physical stress during the competition period increased serum autoantibodies Anti-ACTC1 by 18.0%, Anti-MYH7B by 20.1%, and Anti-cTnI by 40.9% in professional basketball players, indicating potential myocardial stress.
Why the study?
The study aimed to assess the diagnostic significance of Anti-ACTC1, Anti-MYH7B, and Anti-cTnI autoantibodies and their relationship with electrocardiography in predicting cardiomyocyte damage in athletes under physical stress.
Does intense physical stress increase autoimmune bioindicators of cardiomyocyte damage in professional athletes compared to usual motor activity?
Observational (n=35)
No
Does intense physical stress increase autoimmune bioindicators of cardiomyocyte damage in professional athletes compared to usual motor activity?
Intense physical stress in professional athletes is associated with increased autoantibodies to cardiomyocyte proteins and ECG changes, suggesting subclinical myocardial microtrauma and remodeling.
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Autoantibody elevation may indicate myocardial microtrauma in stressed athletes; leaves open diagnostic utility pending validation.
Levochkina et al. (2024) conducted an observational in Cardiomyocyte damage (n=35). Intense physical stress (professional basketball training) vs. Usual amount of total motor activity was evaluated on Increase in serum autoantibodies (Anti-ACTC1, Anti-MYH7B, Anti-cTnI) during the competitive period compared to the preparatory period. Intense physical stress during the competition period increased serum autoantibodies Anti-ACTC1 by 18.0%, Anti-MYH7B by 20.1%, and Anti-cTnI by 40.9% in professional basketball players, indicating potential myocardial stress.
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