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March 7, 2018BMC UrologyOpen Access

Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies

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Key result

Calcium channel blocker use was associated with a slightly increased risk of prostate cancer (RR 1.08), while ACE inhibitors, ARBs, beta-blockers, and diuretics showed no significant association.

Why the study?

Do antihypertensive drugs increase the risk of prostate cancer?

Population

21 observational studies evaluating the relationship between antihypertensive drugs usage and prostate…

Comparison

Antihypertensive drugs as a class and specific… vs Non-users of the specific antihypertensive drug…

Design

Meta-analysis

Follow-up

more than 5 years in most cohort studies

Authors

LCLiang CaoConvalife (China)SZSha ZhangAir Force Medical UniversityCJChengming JiaShaanxi Provincial Hospital of Traditional Chinese Medicine

Discussion

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Member takes

Overview

Does not support changing antihypertensive therapy; leaves open a modest prostate cancer association with calcium channel blockers for prospective study.

Study Design

Type

Meta-Analysis

Structured PICO

Do antihypertensive drugs increase the risk of prostate cancer?

P
Population
A meta-analysis of 21 observational studies (12 cohort and 9 case-control) evaluating the association between various classes of antihypertensive drugs and the risk of incident prostate cancer.
E
Exposure
Antihypertensive drugs as a class and specific categories including angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), calcium-channel blockers (CCB), beta-blockers, diuretics, and antiadrenergic agents.
C
Comparator
Non-users of the specific antihypertensive drug or non-users of any antihypertensive medication.
O
Outcome
Risk of prostate cancerhard clinical

Main Result

Relative Risk: 1.08 (95% CI 1–1.16)

This meta-analysis suggests that most antihypertensive drugs do not increase prostate cancer risk, though calcium channel blockers may be associated with a slight increase in risk.

Limitations

  • Considerable heterogeneity existed among the included studies
  • Small sample sizes for the analyses on the association between diuretics or antiadrenergic drugs and prostate cancer risk
  • Publication bias was not assessed
  • Lack of relevant data prevented a dose-response meta-analysis

Cite This Study

Cao et al. (2018) conducted a meta-analysis in Prostate cancer. Antihypertensive drugs (Calcium channel blockers) vs. No use of the specific antihypertensive drug was evaluated on Risk of prostate cancer (RR 1.08, 95% CI 1.00-1.16). Calcium channel blocker use was associated with a slightly increased risk of prostate cancer (RR 1.08), while ACE inhibitors, ARBs, beta-blockers, and diuretics showed no significant association.

synapsesocial.com/papers/6a86fcf83d239a2773cf82efhttps://doi.org/10.1186/s12894-018-0318-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between captopril, other antihypertensive drugs and risk of prostate cancer2003 · 118 citations
  2. 2Calcium channel blocker use and the risk of prostate cancer☆1998 · 33 citations
  3. 3Calcium Channel Blockers and the Risk of Cancer1998 · 152 citations
  4. 4Effects of blood pressure lowering on outcome incidence in hypertension2014 · 276 citations
  5. 5Cancer Risk in Users of Calcium Channel Blockers1997 · 117 citations