Key result
Intracellular Mg2+ enhances BK channel function under physiological conditions by activating mslo1 channels independently of Ca2+ and voltage.
Population
mslo1 and mslo3 BK-type Ca2+-activated K+ channels
Design
Preclinical
Authors
Loading...
Supports further investigation of Mg2+ effects on BK channels in disease models; leaves open clinical relevance pending human studies.
Intracellular Mg2+ enhances BK channel function by binding to open conformations independently of Ca2+ and voltage, despite competitively inhibiting Ca2+-dependent activation.
Shi et al. (2001) studied this question. Intracellular Mg2+ was evaluated on BK channel function. Intracellular Mg2+ enhances BK channel function under physiological conditions by activating mslo1 channels independently of Ca2+ and voltage.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: