Key result
Macroscopic ionic current recordings identified two binding sites on the cytosolic N terminus of β1 that regulate calcium and magnesium sensitivity in BK channels.
Population
Large conductance Ca(2+)- and voltage-activated potassium (BK) channels (mSlo1 α and β1 subunits)
Design
Preclinical
Authors
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Identifies candidate sites for BK modulation; leaves open relevance to human cardiovascular physiology.
This study provides a comprehensive structural model and mechanistic insights into the gating of BK channels by identifying key binding sites between the mSlo1 α and β1 subunits.
Liu et al. (2014) studied this question. Macroscopic ionic current recordings in various Ca(2+) and Mg(2+) concentrations was evaluated on Identification of binding sites on the cytosolic N terminus of β1. Macroscopic ionic current recordings identified two binding sites on the cytosolic N terminus of β1 that regulate calcium and magnesium sensitivity in BK channels.
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