Why the study?
Prospective multinational data on the concomitant pharmacological management of DM and HF are scarce.
Does the use of specific anti-diabetic medications, such as metformin, improve the composite of all-cause mortality or heart failure hospitalization in Asian patients with HFrEF and diabetes mellitus?
Does the use of specific anti-diabetic medications, such as metformin, improve the composite of all-cause mortality or heart failure hospitalization in Asian patients with HFrEF and diabetes mellitus?
In Asian patients with HFrEF and diabetes, metformin is underutilized despite being associated with a trend toward improved clinical outcomes compared to other commonly prescribed agents like sulfonylureas.
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May inform anti-diabetic choices in Asian HF-DM; extends regional registry data but leaves open causal effects on outcomes.
Chia et al. (2019) studied this question.
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