June 1, 1975Journal of Biological ChemistryOpen Access

The role of calcium in regulation of cyclic nucleotide content in human umbilical artery.

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Population

Term gestational human umbilical artery segments

Comparison

Incubation in Ca-2+-free medium, readdition of… vs Incubation in normal Ca-2+ containing medium

Design

Preclinical

Authors

RCRonald I. ClymanUniversity of California, San Francisco ABA S BlacksinLung Institute JSJ A SandlerUniversity of California, San Diego

Discussion

Member takes

Implication

Suggests distinct Ca2+-dependent and -independent cGMP pathways in vascular tissue; leaves open relevance to human physiology or therapies.

Structured PICO

Population

Term gestational human umbilical artery segments

Intervention

Incubation in Ca-2+-free medium, readdition of Ca-2+ or Sr-2+, and exposure to various agonists (histamine, acetylcholine, bradykinin, K+, serotonin, PGE1) and ionophores

Comparator

Incubation in normal Ca-2+ containing medium

Outcome

Content of guanosine 3':5'-monophosphate (cGMP) and adenosine 3':5'-monophosphate (cAMP)surrogate

The human umbilical artery possesses two separate mechanisms for controlling cGMP synthesis that are influenced differently by calcium.

Cite This Study

Clyman et al. (1975) studied this question.

synapsesocial.com/papers/6a871df83a1d8ec5fdd3dfca https://doi.org/10.1016/s0021-9258(19)41361-6

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Implication

Suggests distinct Ca2+-dependent and -independent cGMP pathways in vascular tissue; leaves open relevance to human physiology or therapies.

The role of calcium in regulation of cyclic nucleotide content in human umbilical artery.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The role of calcium in regulation of cyclic nucleotide content in human umbilical artery.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider