Viral double-stranded RNA can directly induce cytopathic effects in mammalian cells without requiring viral replication or de novo protein synthesis.
dsRNA may directly trigger cytopathic effects; hypothesis-generating for viral pathogenesis and leaves open in vivo relevance or therapeutic implications.
Noninfectious bovine enterovirus double-stranded RNA induces cytopathic effects when added to mammalian cells in culture. This is demonstrated by (51)Cr release from prelabeled murine lymphoma cells and trypan blue uptake. Also, the induction of cell death by this viral RNA occurs in the presence of inhibitors of protein synthesis (cycloheximide and puromycin). The possible role and mechanism of viral, double-stranded RNA as a cytopathic agent in virally infected cells are discussed.
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Cordell-Stewart et al. (1973) studied this question.
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