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January 1, 1977Circulation ResearchOpen Access

Paradoxical dynamic interaction of heart period and vagal activity on atrioventricular conduction in the dog.

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Population

Dogs (preclinical model)

Comparison

Simultaneously changing heart period and single… vs Paced heart preparation and changes in heart…

Design

Preclinical

Authors

PMPaul MartinUniversity of Manchester

Discussion

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Overview

Indicates vagal activity attenuates AV delay during rate slowing in animals; leaves open translation to human electrophysiology.

Structured PICO

P
Population
Dogs (preclinical model)
I
Intervention
Simultaneously changing heart period and single vagal stimuli (unpaced heart preparation)
C
Comparator
Paced heart preparation and changes in heart period alone without vagal stimulation (crushed sinoatrial node)
O
Outcome
Atrioventricular conduction (AV interval)surrogate

The study demonstrates a paradoxical dynamic interaction where increased vagal activity associated with a change in heart period results in less AV conduction time than changes in heart period alone, driven by AV nodal tissue mechanisms and shifts in pacemaker sites.

Cite This Study

Paul Martin (1977) studied this question.

synapsesocial.com/papers/6a871e7252b690c5299eb7c8https://doi.org/10.1161/01.res.40.1.81
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intra-SA-nodal pacemaker shifts induced by autonomic nerve stimulation in the dog1975 · 38 citations
  2. 2Excitation Sequences of the Atrial Septum and the AV Node in Isolated Hearts of the Dog and Rabbit1971 · 139 citations
  3. 3Effect of Atrial Stimulation Site on the Electrophysiological Properties of the Atrioventricular Node in Man1974 · 85 citations
  4. 4Influence of Brief Vagal and Stellate Nerve Stimulation on Pacemaker Activity and Conduction within the Atrioventricular Conduction System of the Dog1973 · 142 citations
  5. 5Studies on Left Atrial Automaticity in Dogs1970 · 28 citations