Why the study?
Patients with Fontan circulation are at high risk for atrial tachyarrhythmias, prompting this study to examine the efficacy and safety of amiodarone for managing these arrhythmias in adult Fontan patients.
What is the efficacy and safety of amiodarone in the management of atrial arrhythmias in adult Fontan patients?
What is the efficacy and safety of amiodarone in the management of atrial arrhythmias in adult Fontan patients?
Amiodarone has acceptable short-term efficacy for atrial arrhythmias in adult Fontan patients, but long-term use is limited by reduced efficacy and high rates of adverse effects, particularly thyrotoxicosis which exacerbates heart failure.
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Amiodarone warrants close monitoring for side effects in adult Fontan patients; leaves open need for RCTs on long-term strategies.
Kawada et al. (2020) studied this question.
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