Why the study?
How do hormonal regulators influence the phosphorylation status of circulating IGFBP-1?
Population
Human subjects, including women on oral contraceptives versus no medication, and 3 subjects with Laron's…
Comparison
Hormonal stimuli including insulin, glucagon… vs Baseline levels or no medication
Design
Other
Follow-up
up to 5 hours for acute stimuli
Authors
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Hormonal IGFBP-1 increases are phosphorylation-specific; leaves open distinct regulatory mechanisms for lesser-phosphorylated species.
How do hormonal regulators influence the phosphorylation status of circulating IGFBP-1?
Hormonal regulation of IGFBP-1 exclusively affects its highly phosphorylated species, suggesting different regulatory mechanisms for non- and lesser phosphorylated variants.
Westwood et al. (1995) studied this question.
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