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May 27, 1976Journal of Fluid Mechanics

Unsteady flow in a branch

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Population

Two-dimensional bifurcation model of an arterial branch

Comparison

Pulsatile flow modeling (two flux waves) vs Steady flow estimates

Design

Preclinical

Authors

VOV. O’BrienSanta Clara UniversityLELouis W. EhrlichJohns Hopkins University Applied Physics LaboratoryMFMorton H. FriedmanWest Virginia University

Discussion

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Implication

Caution against applying animal pulsatile flow data clinically; leaves open human validation of shear effects on plaque.

Structured PICO

P
Population
Two-dimensional bifurcation model of an arterial branch
I
Intervention
Pulsatile flow modeling (two flux waves)
C
Comparator
Steady flow estimates
O
Outcome
Temporal and spatial distributions of shear and separationsurrogate

Pulsatile flow models in arterial bifurcations reveal significant differences in shear and separation compared to steady flow, providing insights into the focal tendency of atherosclerotic plaque formation.

Cite This Study

O’Brien et al. (1976) studied this question.

synapsesocial.com/papers/6a873449b688e10ffe82d002https://doi.org/10.1017/s0022112076000244
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Hemodynamic Concept of Atherosclerosis1960 · 67 citations
  2. 2Atheroma and arterial wall shear - Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis1971 · 1,359 citations
  3. 3The Role of Vascular Dynamics in the Development of Atherosclerosis1965 · 100 citations
  4. 4Computation of fluid-dynamical contributions to atherosclerosis at arterial bifurcations1972 · 28 citations
  5. 5Finite-difference and finite-element methods of approximation1971 · 8 citations