What question did this study set out to answer?

To determine whether ultrasonic tissue characterization using integrated backscatter can detect subclinical myocardial contractile impairment and structural changes in chronic hemodialysis patients.

March 1, 2000Angiology

Sensitive Detection of Myocardial Contraction Abnormality in Chronic Hemodialysis Patients by Ultrasonic Tissue Characterization with Integrated Backscatter

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Why the study?

Does ultrasonic tissue characterization with integrated backscatter detect subclinical myocardial contraction abnormalities in chronic hemodialysis patients compared to normal controls?

Population

18 hemodialysis patients and 11 age-matched normal controls

Comparison

Ultrasonic tissue characterization with… vs Age-matched normal controls

Design

Case-control

Authors

KMKatsufumi MizushigeOregon Health & Science University TTTakeshi TokudomeYokohama City University MSMakoto SekiASKA Pharmaceutical (Japan)

Discussion

Member takes

Implication

CV-IB may detect subclinical myocardial abnormalities in HD patients; leaves open whether it predicts outcomes or guides therapy.

Key Points

To determine whether ultrasonic tissue characterization using integrated backscatter can detect subclinical myocardial contractile impairment and structural changes in chronic hemodialysis patients.
Evaluated 18 chronic hemodialysis patients (mean dialysis duration: 102 ± 84 months; mean age: 57.6 ± 9.7 years) and 11 age-matched normal controls.
Measured the cyclic variation of integrated backscatter (CV-IB) at the interventricular septum (IVS) and left ventricular posterior wall (PW).
Compared CV-IB findings with standard echocardiographic measures of systolic performance (%FS, %Th) and Doppler transmitral diastolic inflow velocities.
CV-IB was significantly lower in hemodialysis patients than in controls at the interventricular septum (6.2 ± 1.1 dB vs 8.2 ± 1.1 dB, p = 0.0003) and posterior wall (8.4 ± 2.2 dB vs 10.3 ± 1.3 dB, p = 0.025).
Systolic indices (%FS and %Th) showed no significant difference between groups, while diastolic parameters demonstrated impaired filling in hemodialysis patients (E/A ratio: 0.7 ± 0.2 vs 1.1 ± 0.7, p = 0.049; deceleration time: 200 ± 28 msec vs 159 ± 30 msec, p = 0.0082).

Structured PICO

Does ultrasonic tissue characterization with integrated backscatter detect subclinical myocardial contraction abnormalities in chronic hemodialysis patients compared to normal controls?

Population

18 hemodialysis (HD) patients (duration: 102 +/- 84 months, mean age: 57.6 +/- 9.7 years) and 11 age-matched normal controls

Intervention

Ultrasonic tissue characterization with integrated backscatter

Comparator

Age-matched normal controls

Outcome

Cyclic variation of integrated backscatter (CV-IB) at interventricular septum (IVS) and left ventricular posterior wall (PW)surrogate

Ultrasonic tissue characterization with integrated backscatter can detect subclinical myocardial damage and diastolic dysfunction in hemodialysis patients prior to the onset of overt systolic dysfunction.

Cite This Study

Mizushige et al. (2000) studied this question.

synapsesocial.com/papers/6a87a375e77e40295ee67ec9 https://doi.org/10.1177/000331970005100306

Topics

Hypertension management

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Sensitive Detection of Myocardial Contraction Abnormality in Chronic Hemodialysis Patients by Ultrasonic Tissue Characterization with Integrated Backscatter

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Sensitive Detection of Myocardial Contraction Abnormality in Chronic Hemodialysis Patients by Ultrasonic Tissue Characterization with Integrated Backscatter

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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