Why the study?
Does diltiazem improve blood pressure control in patients with essential mild to moderate hypertension?
Does diltiazem improve blood pressure control in patients with essential mild to moderate hypertension?
Long-term treatment with diltiazem (90-270 mg/day) provides effective blood pressure control in mild to moderate essential hypertension with minimal side effects.
Cohort data should not change hypertension practice; leaves open need for RCTs to confirm diltiazem's sustained efficacy.
A group of 48 patients with essential mild to moderate hypertension were treated with the calcium-channel blocker diltiazem (90-270 mg/day) for one year. Adequate blood pressure control was achieved in all patients. No tolerance developed during the one-year treatment period. The drug is almost free from side effects. Very few patients develop fluid retention, which can be controlled by adding a diuretic.
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W. Klein (1987) studied this question.
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