September 5, 2007DiabetesOpen Access

Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling

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Population

Insulin-deficient diabetic mice heterozygous for the Ins2(Akita) mutation and nondiabetic littermates

Comparison

Insulin treatment or intracellular infusion of… vs Untreated myocytes from diabetic mice and…

Design

Preclinical

Authors

ZLZhongju LuStony Brook School YJYaping JiangYangpu Hospital of Tongji University XXXinhua XuYibin University

Discussion

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Implication

Hypothesis-generating for PI 3-kinase in diabetic cardiomyopathy; human studies needed before clinical relevance.

Structured PICO

Population

Insulin-deficient diabetic mice heterozygous for the Ins2(Akita) mutation and nondiabetic littermates

Intervention

Insulin treatment or intracellular infusion of PI 3,4,5-trisphosphate [PI(3,4,5)P(3)]

Comparator

Untreated myocytes from diabetic mice and myocytes from nondiabetic littermates

Outcome

Cardiac L-type Ca(2+) current (I(Ca,L)) density and PI 3-kinase signalingsurrogate

Decreased PI 3-kinase signaling in type 1 diabetic mice reduces Ca2+ entry through the LTCC, potentially contributing to diabetic cardiomyopathy and contractility defects.

Cite This Study

Lu et al. (2007) studied this question.

synapsesocial.com/papers/6a87afab9842aaac2ffb05a5 https://doi.org/10.2337/db06-1629

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Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider