The DA1 receptor/adenylyl cyclase coupling defect in spontaneously hypertensive rats is organ-specific, occurring in the proximal convoluted tubule but not the striatum, and is present early in life before elevated renal dopamine levels.
No takes yet. Share an insight, caveat, or question.
Animal data show early kidney-specific DA1-AC defect in hypertension models; leaves open human relevance and clinical translation.
Felder et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: