Population
Rabbits made hypertensive by partial constriction of the upper abdominal aorta
Comparison
Induction of hypertension by coarctation of the… vs Vessels distal to the ligature
Design
Preclinical
Follow-up
Two weeks
Authors
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Differentiates mass- versus sensitivity-driven norepinephrine hyperresponsiveness in hypertensive vessels; leaves open human translation.
In a rabbit model of hypertension, increased responsiveness to norepinephrine in hypertensive arteries is likely due to increased muscle mass, while increased responsiveness in veins is due to increased sensitivity.
Bevan et al. (1975) studied this question.
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