October 15, 1991The Journal of Cell BiologyOpen Access

Fiber type- and position-dependent expression of a myosin light chain-CAT transgene detected with a novel histochemical stain for CAT.

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Population

Transgenic mice in which regulatory sequences from a myosin light chain gene are linked to the…

Design

Preclinical

Authors

MDMaria J. DonoghueSociety for Neuroscience JAJohn AlvarezUniversity of California, San Francisco JMJohn P. MerlieBoston University

Discussion

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Implication

No clinical implications; leaves open distinct transcriptional regulators of skeletal muscle gene expression in humans.

Structured PICO

Population

Transgenic mice in which regulatory sequences from a myosin light chain gene (MLC1f/3f) are linked to the chloramphenicol acetyltransferase (CAT) gene

Intervention

Histochemical stain for CAT

Outcome

Cellular basis of patterns of CAT expressionsurrogate

Fiber type and position affect CAT expression independently in MLC1f/3f-CAT transgenic mice, suggesting separate transcriptional regulators.

Cite This Study

Donoghue et al. (1991) studied this question.

synapsesocial.com/papers/6a87c52e6e1dca10b7bb58bf https://doi.org/10.1083/jcb.115.2.423

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Fiber type- and position-dependent expression of a myosin light chain-CAT transgene detected with a novel histochemical stain for CAT.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Fiber type- and position-dependent expression of a myosin light chain-CAT transgene detected with a novel histochemical stain for CAT.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider